- DESOTO COUNTY (MS)
- Public & Private Schools
- Population 161,252
- Zip Codes 38671, 38632, 38672, 38637, 38680, 38641, 38686, 38611, 38651, 38654
DeSoto County is a county located in the U.S. state of Mississippi. As of the 2010 census, the population was 161,252, making it the third-most populous county in Mississippi. Its county seat is Hernando. DeSoto County is part of the Memphis, TN-MS-AR Metropolitan Statistical Area (MSA). It is the second-most populous county in the MSA. The county has lowland areas that were developed in the 19th century for cotton plantations, and hill country in the eastern part of the county.